Disposable cartridge and method for an assay of a biological sam

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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422 50, 422 55, 422 58, 422 681, 422 72, 422 8206, 422 8207, 4352871, 4352872, 4352876, 4352884, 4352885, 4352887, 435808, 435810, 435973, 436 45, 436 70, 436164, 436165, 436172, 436179, 436514, 436809, G01N 3353, G01N 33558

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active

059121343

ABSTRACT:
A cartridge is provided to present a biological sample for analysis by an imaging instrument. The cartridge of the invention utilizes a series of channels, capillaries, reservoirs and stop junctions to precisely move a sample, reagent and diluent through the cartridge as a function of the sum of capillary, gravitational and low centrifugal forces. The operator applies a precise amount of sample to the cartridge; therefore, the cartridge fluidics need not meter the sample prior to dilution. A practical and cost effective cartridge and assay process is disclosed which overcomes many of the limitations of the prior art. Such a cartridge is especially useful with fixed volume assays which permit low centrifugal accelerations to move the fluids within the cartridge.

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patent: 5338427 (1994-08-01), Shartle et al.
patent: 5472603 (1995-12-01), Schembri

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