Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1994-02-16
1995-12-26
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
530412, 530415, 530344, 564292, 564295, C07K 114, C07K 116, C07K 118, C07C21162
Patent
active
054789249
ABSTRACT:
A method for the purification of proteins by displacement chromatography on ion exchange media using low molecular weight displacers is disclosed. Several classes of low molecular weight, charged species are exemplified, including aminoacids, peptides, antibiotics and dendrimeric polymers. Novel compounds useful as displacers are dendrimers of formula ##STR1## wherein R.sup.1 is lower alkyl, n is 2 to 6, and X is a common counter anion and similar dendritic polymers based thereon.
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Cramer Steven M.
Jayaraman Guhan
Kundu Amitava
Li Yufei
Moore James A.
Degen Nancy J.
Wityshyn Michael G.
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