Dispersion for pulmonary delivery of a bioactive agent

Details Dispersion for pulmonary delivery of a bioactive agent Dispersion for pulmonary delivery of a bioactive agent

2008-05-27

2011-12-20

Alstrum-Acevedo, James H. (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S045000, C514S005900, C514S180000, C514S181000, C514S649000

Reexamination Certificate

active

08080263

ABSTRACT:
Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.

REFERENCES:
patent: 3014844 (1961-12-01), Thiel et al.
patent: 3975512 (1976-08-01), Long
patent: 4590206 (1986-05-01), Forrester et al.
patent: 4818542 (1989-04-01), DeLuca et al.
patent: 4904479 (1990-02-01), Illum
patent: 5011678 (1991-04-01), Wang et al.
patent: 5069936 (1991-12-01), Yen
patent: 5118494 (1992-06-01), Schultz et al.
patent: 5126123 (1992-06-01), Johnson
patent: 5173298 (1992-12-01), Meadows
patent: 5182097 (1993-01-01), Byron et al.
patent: 5190029 (1993-03-01), Byron et al.
patent: 5208226 (1993-05-01), Palmer
patent: 5225183 (1993-07-01), Purewal et al.
patent: 5230884 (1993-07-01), Evans et al.
patent: 5254330 (1993-10-01), Ganderton et al.
patent: 5260306 (1993-11-01), Boardman et al.
patent: 5284656 (1994-02-01), Platz et al.
patent: 5299566 (1994-04-01), Davis et al.
patent: 5308620 (1994-05-01), Yen
patent: 5348730 (1994-09-01), Greenleaf et al.
patent: 5376359 (1994-12-01), Johnson
patent: 5437272 (1995-08-01), Fuhrman
patent: 5470885 (1995-11-01), Fuhrman et al.
patent: 5474759 (1995-12-01), Fassberg et al.
patent: 5490498 (1996-02-01), Faithfull et al.
patent: 5492688 (1996-02-01), Byron et al.
patent: 5506203 (1996-04-01), Backstrom et al.
patent: 5518709 (1996-05-01), Sutton et al.
patent: 5518731 (1996-05-01), Meadows
patent: 5518998 (1996-05-01), Backstrom et al.
patent: 5540225 (1996-07-01), Schutt
patent: 5547656 (1996-08-01), Unger
patent: 5562608 (1996-10-01), Sekins et al.
patent: 5569450 (1996-10-01), Duan et al.
patent: 5580575 (1996-12-01), Unger et al.
patent: 5603918 (1997-02-01), McNamara
patent: 5605673 (1997-02-01), Schutt et al.
patent: 5605674 (1997-02-01), Purewal et al.
patent: 5612053 (1997-03-01), Baichwal et al.
patent: 5616311 (1997-04-01), Yen
patent: 5635159 (1997-06-01), Fu Lu et al.
patent: 5635161 (1997-06-01), Adjei et al.
patent: 5653961 (1997-08-01), McNally et al.
patent: 5653962 (1997-08-01), Akehurst et al.
patent: 5654007 (1997-08-01), Johnson et al.
patent: 5658549 (1997-08-01), Akehurst et al.
patent: 5667809 (1997-09-01), Trevino et al.
patent: 5674471 (1997-10-01), Akehurst et al.
patent: 5674472 (1997-10-01), Akehurst et al.
patent: 5674473 (1997-10-01), Purewal et al.
patent: 5676929 (1997-10-01), Akehurst et al.
patent: 5681545 (1997-10-01), Purewal et al.
patent: 5683676 (1997-11-01), Akehurst et al.
patent: 5683677 (1997-11-01), Purewal et al.
patent: 5688782 (1997-11-01), Neale et al.
patent: 5690954 (1997-11-01), Illum
patent: 5695743 (1997-12-01), Purewal et al.
patent: 5695744 (1997-12-01), Neale et al.
patent: 5707352 (1998-01-01), Sekins et al.
patent: 5718222 (1998-02-01), Lloyd et al.
patent: 5718921 (1998-02-01), Mathiowitz et al.
patent: 5720940 (1998-02-01), Purewal et al.
patent: 5724957 (1998-03-01), Rubsamen et al.
patent: 5725841 (1998-03-01), Duan et al.
patent: 5725871 (1998-03-01), Illum
patent: 5735263 (1998-04-01), Rubsamen et al.
patent: 5736124 (1998-04-01), Akehurst et al.
patent: 5741478 (1998-04-01), Osborne et al.
patent: 5741522 (1998-04-01), Violante et al.
patent: 5743250 (1998-04-01), Gonda et al.
patent: 5743252 (1998-04-01), Rubsamen et al.
patent: 5744123 (1998-04-01), Akehurst et al.
patent: 5744166 (1998-04-01), Illum
patent: 5747445 (1998-05-01), Backstrom et al.
patent: 5755218 (1998-05-01), Johansson et al.
patent: 5756104 (1998-05-01), de Haan et al.
patent: 5766573 (1998-06-01), Purewal et al.
patent: 5770187 (1998-06-01), Hasebe et al.
patent: 5770222 (1998-06-01), Unger et al.
patent: 5770559 (1998-06-01), Manning et al.
patent: 5770585 (1998-06-01), Kaufman et al.
patent: 5804212 (1998-09-01), Illum
patent: 5811406 (1998-09-01), Szoka, Jr. et al.
patent: 5814607 (1998-09-01), Patton
patent: 5817293 (1998-10-01), Akehurst et al.
patent: 5820883 (1998-10-01), Tice et al.
patent: 5829435 (1998-11-01), Rubsamen et al.
patent: 5830430 (1998-11-01), Unger et al.
patent: 5830853 (1998-11-01), Backstrom et al.
patent: 5855913 (1999-01-01), Hanes et al.
patent: 5856367 (1999-01-01), Barrows et al.
patent: 5858784 (1999-01-01), Debs et al.
patent: 5861175 (1999-01-01), Walters et al.
patent: 5863554 (1999-01-01), Illum
patent: 5874063 (1999-02-01), Briggner et al.
patent: 5874064 (1999-02-01), Edwards et al.
patent: 5891844 (1999-04-01), Hafner
patent: 5898028 (1999-04-01), Jensen et al.
patent: 6309623 (2001-10-01), Weers et al.
patent: 6433040 (2002-08-01), Dellamary et al.
patent: 6565885 (2003-05-01), Tarara et al.
patent: 6630169 (2003-10-01), Bot et al.
patent: 6638495 (2003-10-01), Weers et al.
patent: 6946117 (2005-09-01), Schutt et al.
patent: 7141236 (2006-11-01), Bot et al.
patent: 7205343 (2007-04-01), Dellamary et al.
patent: 7306787 (2007-12-01), Tarara et al.
patent: 7393544 (2008-07-01), Dellamary et al.
patent: 7628978 (2009-12-01), Weers et al.
patent: 2036844 (1991-08-01), None
patent: 2136704 (1995-05-01), None
patent: 2304820 (1999-04-01), None
patent: 2304973 (1999-04-01), None
patent: 2304975 (1999-04-01), None
patent: 0274431 (1988-07-01), None
patent: 0372777 (1993-01-01), None
patent: 0391896 (1994-03-01), None
patent: 0536204 (1994-04-01), None
patent: 0611567 (1994-08-01), None
patent: 0553298 (1994-11-01), None
patent: 0653205 (1995-05-01), None
patent: 0656206 (1995-06-01), None
patent: 0658101 (1995-06-01), None
patent: 0513127 (1995-07-01), None
patent: 0493437 (1995-08-01), None
patent: 0556256 (1995-08-01), None
patent: 0616525 (1995-09-01), None
patent: 0499344 (1995-10-01), None
patent: 0587790 (1996-01-01), None
patent: 0605578 (1996-01-01), None
patent: 0588897 (1996-02-01), None
patent: 0536235 (1997-01-01), None
patent: 0539522 (1998-12-01), None
patent: WO 9104011 (1991-04-01), None
patent: WO 9111173 (1991-08-01), None
patent: WO 9112823 (1991-09-01), None
patent: WO 9200107 (1992-01-01), None
patent: WO 9211050 (1992-07-01), None
patent: WO 9214444 (1992-09-01), None
patent: WO 9218164 (1992-10-01), None
patent: WO 9311744 (1993-06-01), None
patent: WO 9311745 (1993-06-01), None
patent: WO 9314172 (1993-07-01), None
patent: WO 9408627 (1994-04-01), None
patent: WO 9500128 (1995-01-01), None
patent: WO 9527476 (1995-01-01), None
patent: WO 9505194 (1995-02-01), None
patent: WO 9515118 (1995-06-01), None
patent: WO 9517195 (1995-06-01), None
patent: WO 9523613 (1995-09-01), None
patent: WO 9524892 (1995-09-01), None
patent: WO 9531182 (1995-11-01), None
patent: WO 9531964 (1995-11-01), None
patent: WO 9609814 (1996-04-01), None
patent: WO 9615814 (1996-05-01), None
patent: WO 9618388 (1996-06-01), None
patent: WO 9619197 (1996-06-01), None
patent: WO 9619198 (1996-06-01), None
patent: WO 9619199 (1996-06-01), None
patent: WO 9619968 (1996-07-01), None
patent: WO 9626746 (1996-09-01), None
patent: WO 9632149 (1996-10-01), None
patent: WO 9640068 (1996-12-01), None
patent: WO 9703649 (1997-02-01), None
patent: WO 9735562 (1997-10-01), None
patent: WO 9736574 (1997-10-01), None
patent: WO 9736578 (1997-10-01), None
patent: WO 9740819 (1997-11-01), None
patent: WO 9741833 (1997-11-01), None
patent: WO 9744012 (1997-11-01), None
patent: WO 9744013 (1997-11-01), None
patent: WO 9800111 (1998-01-01), None
patent: WO 9801161 (1998-01-01), None
patent: WO 9805302 (1998-02-01), None
patent: WO 9808519 (1998-03-01), None
patent: WO 9813031 (1998-04-01), None
patent: WO 9816205 (1998-04-01), None
patent: WO 9817257 (1998-04-01), None
patent: WO 9829097 (1998-07-01), None
patent: WO 9829098 (1998-07-01), None
patent: WO 9829099 (1998-07-01), None
patent: WO 9829140 (1998-07-01), None
patent: WO 98

Affiliated with

Also associated with

Rating

Dispersion for pulmonary delivery of a bioactive agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dispersion for pulmonary delivery of a bioactive agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dispersion for pulmonary delivery of a bioactive agent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4293761