Dispersible antibody compositions and methods for their preparat

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

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A61K 39395

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active

060199687

ABSTRACT:
This invention relates to dispersible antibody compositions and methods for preparing and using these compositions. In particular, the present invention relates to dry powder dispersible antibody compositions wherein antibody conformation is preserved. The compositions have good powder dispersibility and other desirable characteristics for pulmonary delivery of therapeutic antibodies.

REFERENCES:
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patent: 5458135 (1995-10-01), Patton et al.
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Gombotz, Wayne R., et al., The Stabilization of a Human IgM Monoclonal Antibody with Poly(vinylpyrrolidone), Pharm. Res., 11:624-632 (1994).
Maruyama, Kazuo, et al., "Tragetability of Novel Immunoliposomes Modified with Amphipathic Poly(ethylene Glycol)s conjugated at Their Distal Terminals to Monoclonal Antibodies", Biochimica et Biophysica Acta, 1234:74-80 (1995).
Paborji, Mehdi, et al., "Chemical and Physical Stability of Chimeric L6, a Mouse-Human Monoclonal Antibody", Pharm. Res., 11(5):764-771 (1994).
Piazza, Franco M., et al., "Immunotherapy of Respiratory Syncytial Virus Infection in Cotton Rats (Sigmodon fulviventer) Using IgG in a Small-Particle Aerosol", J. Infec. Dis., 166:1422-1424 (1992).
Singh, Brahm Pal, et al., "Heat Aggregation Studies of Phycobilisomes, Ferritin, Insulin, and Immunoglobulin by Dynamic Light Scattering", Biopolymers, 31:1387-1396 (1991).

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