Disopyramide phenyl derivatives and labeled conjugates

Details Disopyramide phenyl derivatives and labeled conjugates Disopyramide phenyl derivatives and labeled conjugates

1985-05-20

1987-03-03

Foelak, Morton

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546336, 435 7, 435188, C07D21356, C12N 996

Patent

active

046476687

ABSTRACT:
Disopyramide immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining disopyramide. The immunogens comprise disopyramide coupled by an ether linkage at a selected singular position on its phenyl ring to an immunogenic carrier material. Likewise, the labeled conjugates and synthetic intermediates are phenyl ether derivatives of disopyramide or precursors thereof. The antibody and labeled conjugates are particularly useful in homogeneous nonradioisotopic immunoassays for measuring disopyramide in biological fluids such as serum.

REFERENCES:
patent: 4079061 (1978-03-01), Berkoff et al.
patent: 4288553 (1981-09-01), Singh et al.
Karim et al., "Species Differences in the Biotransformation of a New Antiarrhythmia Agent: Disopyramide Phosphate", J Pharmaceutical Science, vol. 61(6), 1972, pp. 888-893.

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