Disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate,

Details Disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate, Disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate,

1993-08-04

1995-04-11

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

A61K 3166

Patent

active

054059941

ABSTRACT:
The present invention relates to disodium 4-chlorophenylmethylenebisphosphonate monohydrate. The invention also relates to a method of preparing this form of the monohydrate, as well as to pharmaceutical compositions in which disodium tiludronate monohydrate is present as the active principle.

REFERENCES:
patent: 4746654 (1988-05-01), Breliere et al.
patent: 4876248 (1989-10-01), Breliere et al.
patent: 4922007 (1990-05-01), Kieczykowski et al.
Bonnery et al, Bull. Soc. Chim. (1), 1988, pp. 49-56.
Barbier et al. Agents and Actions v. 16 (1-2) 1985 pp. 41-42.
Bonnery et al; Bulletin de la Societe Chimique de France; No. 1; 1988; pp. 49-56.

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