Disinfecton formulations and methods using D-enantiomeric anti-m

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

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424 9463, 514 2, 514912, A61K 3848, A61K 3700

Patent

active

055498949

ABSTRACT:
A method for disinfecting a contact lens, includes the step of contacting the lens with an effective amount of at least one D-enantiomeric anti-microbial agent for a period of time sufficient to disinfect the lens. A proteolytic enzyme can be used in conjunction with the anti-microbial agent for combined disinfection and cleaning. Contact lens disinfecting compositions comprising a D-enantiomeric anti-microbial agent are also provided.

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Wade et al., All-D Amino Acid-Containing Channel-Forming Antibiotic Peptides, Proc. Natl. Acad. Sci. USA 87, 4761-4765 (Jun. 1990).
Bessalle et al., All-D-magainin: Chirality, Antimicrobial Activity and Proteolytic resistance, FEBS Letters 274, No. 1,2, 151-155 (Nov. 1990).

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