Disialofucoganglioside immunogen and fucoganglioside monosialosy

Details Disialofucoganglioside immunogen and fucoganglioside monosialosy Disialofucoganglioside immunogen and fucoganglioside monosialosy

1989-05-05

1991-04-30

Moskowitz, Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530387, 424 8591, 424 11, 424 9, 424 858, 43524027, 435 723, 935104, 935107, 935110, 436548, 436536, C07H 500, C07K 1528, A61K 3900, G01N 3353

Patent

active

050119206

ABSTRACT:
Disialosyl Le.sup.a (IV.sup.3 NeuAcIII.sup.6 NeuAcIII.sup.4 FucLc.sub.4), a novel human cancer-associated fucoganglioside that is highly immunogenic. Also, a hybridoma cell line (ATCC No. HB 8861) secreting a monoclonal IgG3 antibody (FH7) directed to disialosyl Le.sup.a. The disialosyl Le.sup.a antigen was detected in various cancer tissues and their cell lines but was absent in various normal tissues and blood cells. Sera of patients with various cancers, particularly early cases of colonic and gastric cancers, showed an elevated disialosyl Le.sup.a antigen level, which subsequently decreased after surgical tumor removal.

REFERENCES:
Kannagi et al., pp. 280-294 in Metzgar et al., "Human Tumor Antigens and Specific Tumor Therapy", Alan Rliss Inc., 1980.

Affiliated with

Also associated with

Rating

Disialofucoganglioside immunogen and fucoganglioside monosialosy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Disialofucoganglioside immunogen and fucoganglioside monosialosy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Disialofucoganglioside immunogen and fucoganglioside monosialosy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-641117