Disheveled PDZ modulators

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Details

C435S069700, C435S007100, C530S327000, C530S324000, C530S329000

Reexamination Certificate

active

07977064

ABSTRACT:
The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.

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Bezprozvanny et al., “PDZ Domains; evolving classification”FEBS Letters, Amsterdam, NL 512(1-3) :347-349 (Feb. 13, 2002).
Fuh et al., “Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display”Journal of Biological Chemistry, American Society of Biochemical Biologists, Birmingham, US 275 (28) :21486-21491 (Jul. 14, 2000).
Laura et al., “The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF”Journal of Biological Chemistry, American Society of Biochemical Biologists, Birmingham, US 277(15):12906-12914 (Jan. 30, 2002).
Murthy et al., “Fusion proteins could generate false positives in peptide phage display”BioTechniques26(1):142-149 (Jan. 1999).
Skelton et al., “Origins of PDZ domain ligand specificity. Structure determination and mutagents of the Erbin PDZ domain”Journal of Biological Chemistry278 (9):7645-7654 (Feb. 28, 2003).
Wiedemann et al., “Quantification of PDZ Domain Specificity, Prediction of Ligand Affinity and Rational Design of Super-binding Peptides”Journal of Molecular Biology, London, GB 343(3):703-718 (Oct. 22, 2004).
Wong et al., “Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled”Molecular Cell12(5):1251-1260 (Nov. 2003).
PCT/IPEA International Preliminary Examination Report on Patentability for WO 2007/121147 (Apr. 16, 2008).
PCT/ISA International Search Report for WO 2007/121147 (Oct. 27, 2007).

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