Disease associated calmodulin protein

Details Disease associated calmodulin protein Disease associated calmodulin protein

1997-11-03

2000-04-04

Huff, Sheela

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4353201, 530324, C07H 2104, C12P 2106, C12N 1500, A61K 3800

Patent

active

060463155

ABSTRACT:
The invention provides a human disease associated calmodulin protein (DACP-1) and polynucleotides which identify and encode DACP-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of DACP-1.

REFERENCES:
Celio, M.R., et al., Guidebook to Calcium-Binding Proteins, Oxford University Press, Oxford, UK, pp. 15-20 (1996).
Schwaninger, M., et al., "Inhibition of cAMP-responsive Element-mediated Gene Transcription by Cyclosporin A and FK506 after Membrane Depolarization," The Journal of Biological Chemistry, 268(31):23111-23115 (1993).
Rasmussen, C. and Means, A.R., "Calmodulin, cell growth and gene expression," TINS, 12(11):433-438 (1989).
Robson, K., "Sequence diversity in the intron of the calmodulin gene from Plasmodium falciparum ," Molecular and Biochemical Parasitology, 60:1-8 (1993) (GI 385233 & 385234).
Robson, K., (GI 385233 & 385234), GenBank Sequence Database (Accession M99442) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1993).
Nojima, H. and Sokabe, H., "Structure of a gene for Rat Calmodulin," J. Mol. Biol., 193:439-445 (1987) (GI 55860 & 1334203).
Nojima, H. and Sokabe, H., (GI 55860 & 1334203), GenBank Sequence Database (Accession X13931), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1987).
Koller, M. and Strehler, E.E., "Functional analysis of the promoters of the human CaMIII calmodulin gene and of the intronless gene coding for a calmodulin-like protein," Biochimica et Biophysica Acta, 1163:1-9 (1993) (GI 299637 and GI 825635).
Koller, M. and Strehler, E.E., (GI 299637 & 825635), GenBank Sequence Database (Accession X52606), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (1993).

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