Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Reexamination Certificate
2006-10-18
2008-11-18
Bragdon, Kathleen Kerr (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
C435S069100, C435S193000
Reexamination Certificate
active
07452693
ABSTRACT:
Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster fromStreptomyces atroolivaceusS-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl coenzyme A extender unit onto the ACP domains of all six PKS modules. This finding provides a basis for methods of engineering modular polyketide synthases and polyketide synthase
onribosomal peptide synthetases.
Cheng Yi-Qiang
Shen Ben
Tang Gong-Li
Bragdon Kathleen Kerr
Kim Alexander D
Quarles & Brady LLP
Wisconsin Alumni Research Foundation
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