Discorhabdin compounds and methods of use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546 18, 424573, 4352402, A61K 3144, C07D40114

Patent

active

060573333

ABSTRACT:
Discorhabdin compounds are derived from marine sponges of the genus Batzella or prepared by synthetic methods. These compounds, and pharmaceutical compositions containing them as active ingredients, are useful as immunomodulatory, antitumor agents, and/or caspase inhibitors.

REFERENCES:
patent: 4731366 (1988-03-01), Munro et al.
Blunt, John W., Victoria L. Calder, Graham D. Fenwick, Robin J. Lake, John D. McCombs, Murray H.G. Munro, Nigel B. Perry (1987) "Reverse phase flash chromatography: a method for the rapid partitioning of natural product extracts" Journal of Natural Products 50(2):290-292.
Cheng, Jie-fei, Yasushi Ohizumi, Markus R. Walchli et al. (1988) "Prianosins B, C, and D, Novel Sulfur-Containing Alkaloids with Potent Antineoplastic Activity from the Okinawan Marine Sponge Prianos melanos" J. Org. Chem. 53:4621-4624.
Friedland, R.M., Robert H. Brown, Valeria Gagliardini, Joy Wang, Junying Yuan (1997) "Inhibition of ICE slows ALS in mice" Nature 388:31.
Hara, Hideaki et al. (1997) "Inhibition of interleukin 1.beta. converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage" Proc. Natl. Acad. Sci. USA 94:2007-2012.
Kerr, J.F.R., A.H. Wylllie, A.R. Currie (1972) "Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics" Br. J. Cancer 26:239257.
Kim, Tae-Wan, Warren H. Pettingell, Yong-Keun Jung, Dora M. Kovacs, Rudolph E. Tanzi (1997) Science 277:373-376.
Kobayashi, J. et al. (1987) "Prianosin A, A Novel Antileukemic Alkaloid From The Okinawan Marine Sponge Prianos melanos" Tetrahedron Letters 28(42):4939-4942.
Milligan, C.E. et al. (1995) "Peptide Inhibitors of the ICE Protease Family Arrest Programmed Cell Death of Motoneurons in vivo and In Vitro" Neuron 15:385-393.
Munro, M. H. G. et al. (1987) Bioorganic Marine Chemistry, Scheuer, P. J. (ed.), Verlag Chemie: Heidelberg, vol. 1, Chapter 4, pp. 94-176.
Patel, Tushar, Gregory J. Gores, Scott H. Kaufmann 1996) "The role of proteases during apoptosis" FASEB 10:587-597.
Perry, Nigel B., John W. Blunt, John D. McCombs, Murray H.G. Munro (1986) "Discorhabdin C, a Highly Cytotoxic Pigment from a Sponge of the Genus Latrunculia" J. Org. Chem. 51:5476-5478.
Perry, Nigel B., John W. Blunt, Murray H. G. Munro (1988) "Cytotoxic Pigments From New Zealand Sponges Of The Genus Latrunculia: Discorhabdins A, B and C" Tetrahedron Letters 44(6):1727-1734.
Perry, Nigel B., John W. Blunt, Murray H.G. Munro (1988) "Discorhabdin D, an Antitumor Alkaloid from the Sponges Latrunculia brevis and Prianos sp. " J. Org. Chem. 53:4127-4128.
Schwartz, Lawrence M. and Carolanne E. Milligan (1996) "Cold thoughts of death: the role of ICE proteases in neuronal cell death" Trends in Neurosciences 19:555-562.
Sekine, Chiyoko et al. (1996) "Fas-Mediated Stimulation Induces IL-8 Secretion by Rheumatoid Arthritis Synoviocytes Independently of CPP32-Mediated Apoptosis" Biochem. Biophys. Res. Commun. 228:14-21.
Theriot, Julie A. and Lisa L. Satterwhite (1997) "New wrinkles in cytokinesis" Nature 385:388-389.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Discorhabdin compounds and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Discorhabdin compounds and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Discorhabdin compounds and methods of use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1594101

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.