Discontinuous probe design using hybritope mapping

Details Discontinuous probe design using hybritope mapping Discontinuous probe design using hybritope mapping

1995-05-05

1998-04-07

Campbell, Eggerton A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, C12Q 168, C12P 1934

Patent

active

057363277

ABSTRACT:
This invention provides a method of detecting or determining a binding oligonucleotide comprising a nucleotide sequence which binds within a known nucleotide sequence of a target nucleic acid using a technique called hybritope mapping. This invention also provides a method of using hybritope mapping to obtain discontinuous probes that bind to a target nucleic acid.

REFERENCES:
patent: 4868105 (1989-09-01), Urdea et al.
European Search Report for PCT Application No. US 95/15779.
Cload et al., J. Am Chem Soc. (1991) 116: 6324-6326.
Cload et al., J. Am Chem Soc. (1994) 113: 437-442.
Diekman et al, PNAS 84: 8257-8261 (1987).
Chevrie et al, Nucleic Acid Res 18: 6353-6359 (1990).
Cload et al, J. Am Chem. Soc 116: 437-442 (1994).
Doudna et al, PNAS 86: 7402-7406 (1989).
Cload et al, J. Am. Chem. Soc 115: 5005-5014 (1993).

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