Discontinuous and nonsequential polymeric gel systems for separa

Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...

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204469, 2523151, C25B 700, C25B 1500, B01J 1300

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active

059683325

ABSTRACT:
This invention relates to the formation and use of a variable, multilayer system of discrete, discontinuous and nonsequential molecular sieves, comprising of agarose-acrylic gels of distinct composition. Each of the individual gel-layers of the system is designed according to partition and/or retardation coefficients for specific retention and therefore selective separation of selected molecules of different molecular sizes. The unique multilayer composite acrylic gel system of this invention makes it possible to separate micro- and macromolecules which differ in molecular weights by millions of daltons. So isolated any physically defined molecular groups are superiorly suitable for further chemical, physico-chemical or biological characterization.

REFERENCES:
patent: 4189370 (1980-02-01), Boschetti
patent: 5387325 (1995-02-01), Opplt
Allen, Electrophoretic Separation of Pre-stained Lipoproteins on Polyacrylamide Gel Slabs and their Relationship to Other Plasma Proteins, Pharmazeutisches Institut der FU Oct. 6-7, 1972, pp. 287-297.

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