Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-05-07
1991-04-23
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514908, 514460, 549292, A61K 31365
Patent
active
050100998
ABSTRACT:
Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to the formula: ##STR1## wherein: R=--H, --A, --CH.sub.2 --Q, --COA or --COZ,
REFERENCES:
Y. Koto et al., J. Am. Chem. Soc., "Calyculin A, a novel antitumormetabolite from marine sponge Discodermia calyx," 108, pp. 2780-2781 (1986).
D. Vemura et al., J. Am. Chem. Soc., "Norhalichondrin A: An antitumor polyethes macrolide from a marine sponge," 7107, pp. 4796-4798 (1985).
S. Matsunaga et al., Tetrahedron Letters, "Bioactive Marine Metabolites," 25(45), pp. 5165-5168 (1984).
S. Matsunaga et al., Tetrahedron Letters, "Bioactive Marine Metabolites," 26(7), pp. 855-856 (1985).
Burres Neal S.
Gunasekera Malika
Gunasekera Sarath P.
Longley Ross E.
Harbor Branch Oceanographic Institution Inc.
Raymond Richard L.
Russell M. W.
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