Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-12-05
1998-11-24
Owens, Amelia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549292, A61K 3135, C07D30930
Patent
active
058407502
ABSTRACT:
Novel lactone compounds from the marine sponge Discodermia dissoluta have been isolated. These compounds and their analogs have been shown to have activity against mammalian cancer cells, and can be used in treating human patients which host cancer cells, including leukemia, melanoma, and breast, colon, CNS, and lung tumors.
REFERENCES:
patent: 4206221 (1980-06-01), Miller et al.
patent: 4939168 (1990-07-01), Gunasekera et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5157049 (1992-10-01), Haugwitz et al.
Nerenberg, J.B. et al. (1993) "Total Synthesis of the Immunosuppressive Agent (-)-Discodermolide" J. Am. Chem. Soc. 115:12621-12622.
Uemura, D. et al. (1985) "Norhalichondrin A: An Antitumor Polyether Macrolide from a Marine Sponge" J. Am. Chem. Soc. 107:4796-4798.
Faulkner, D.J. (1987) "Marine Natural Products" Natural Products Reports 4:539-576.
Fuchs, D.A., R.K. Johnson (1978) "Crtologic Evidence that Taxol, an Antineoplastic Agent from Taxus brevifolia, Acts as a Mitotic Spindle" Cancer Treatment Reports 62(8):1219-1222.
Schiff, P.B. et al. (1979) "Promotion of microtubule assembly in vitro by taxol" Nature (London) 22:665-667.
Rowinsky, E.K., R.C. Donehower (1995) "Paclitaxel (Taxol)" The New England Journal of Medicine 332(15):1004-1014.
Minale, L. et al. (1976) "Natural Products from Porifera" Fortschr. Chem. org. Naturst. 31:1-72.
Kelly-Borges et al. (1994) "Species Differentiation in the Marine Sponge Genus Discodermia (Demospongiae: Lithistida): the Utility of Ethanol Extract Profiles as Species-Specific Chemotaxonomic Markers" Biochemical Systematics and Ecology 22(4):353-365.
ter Haar, E., H.S. Rosenkranz, E. Hamel, B.W. Day (1996) "Computational and Molecular Modeling Evaluation of the Structural Basis for Tubulin Polymerization Inhibition by Colchicine Site Agents," Bioorganic and Medicinal Chemistry 4(10):1659-1671.
Hung, D.T., J. Chen. S.L. Schreiber (1996) "(+)-Discodermolide binds in microtubules in stoichiometric ratio to tubulin dimers, blocks binding and results in mitotic arrest," Chemistry & Biology 3(4):287-293.
Gunasekera Sarath P.
Longley Ross E.
Pomponi Shirley A.
Harbor Branch Oceanographic Institution Inc.
Owens Amelia
LandOfFree
Discodermolide compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Discodermolide compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Discodermolide compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1702634