Discodermolide compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549292, A61K 3135, C07D30930

Patent

active

058407502

ABSTRACT:
Novel lactone compounds from the marine sponge Discodermia dissoluta have been isolated. These compounds and their analogs have been shown to have activity against mammalian cancer cells, and can be used in treating human patients which host cancer cells, including leukemia, melanoma, and breast, colon, CNS, and lung tumors.

REFERENCES:
patent: 4206221 (1980-06-01), Miller et al.
patent: 4939168 (1990-07-01), Gunasekera et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5157049 (1992-10-01), Haugwitz et al.
Nerenberg, J.B. et al. (1993) "Total Synthesis of the Immunosuppressive Agent (-)-Discodermolide" J. Am. Chem. Soc. 115:12621-12622.
Uemura, D. et al. (1985) "Norhalichondrin A: An Antitumor Polyether Macrolide from a Marine Sponge" J. Am. Chem. Soc. 107:4796-4798.
Faulkner, D.J. (1987) "Marine Natural Products" Natural Products Reports 4:539-576.
Fuchs, D.A., R.K. Johnson (1978) "Crtologic Evidence that Taxol, an Antineoplastic Agent from Taxus brevifolia, Acts as a Mitotic Spindle" Cancer Treatment Reports 62(8):1219-1222.
Schiff, P.B. et al. (1979) "Promotion of microtubule assembly in vitro by taxol" Nature (London) 22:665-667.
Rowinsky, E.K., R.C. Donehower (1995) "Paclitaxel (Taxol)" The New England Journal of Medicine 332(15):1004-1014.
Minale, L. et al. (1976) "Natural Products from Porifera" Fortschr. Chem. org. Naturst. 31:1-72.
Kelly-Borges et al. (1994) "Species Differentiation in the Marine Sponge Genus Discodermia (Demospongiae: Lithistida): the Utility of Ethanol Extract Profiles as Species-Specific Chemotaxonomic Markers" Biochemical Systematics and Ecology 22(4):353-365.
ter Haar, E., H.S. Rosenkranz, E. Hamel, B.W. Day (1996) "Computational and Molecular Modeling Evaluation of the Structural Basis for Tubulin Polymerization Inhibition by Colchicine Site Agents," Bioorganic and Medicinal Chemistry 4(10):1659-1671.
Hung, D.T., J. Chen. S.L. Schreiber (1996) "(+)-Discodermolide binds in microtubules in stoichiometric ratio to tubulin dimers, blocks binding and results in mitotic arrest," Chemistry & Biology 3(4):287-293.

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