Disaggregated solutions of polypeptides, their preparation and u

Details Disaggregated solutions of polypeptides, their preparation and u Disaggregated solutions of polypeptides, their preparation and u

1981-04-16

1983-12-27

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

2601125R, 2601127, 424177, A61K 3726, C07C10352, C07G 700

Patent

active

044230397

ABSTRACT:
The present invention is directed to a solution of a polypeptide, such as, for example, insulin, the solution being prepared and maintained at pH 6.8 to 8.0 and in which the polypeptide remains in solution in disaggregated form. This is accomplished by the use of the bicarbonate ion in the solution, the bicarbonate ion being present in a concentration of 2 mmolar to 2.5 molar.
A method for preparing the polypeptide solution and the use of the solution in maintaining normoglycemia are provided.

REFERENCES:
patent: 2474729 (1949-06-01), Durel et al.
patent: 2902408 (1959-09-01), Bouman et al.
patent: 3014842 (1961-12-01), Schlichtkrull
patent: 3584121 (1971-06-01), Krayenbuhl et al.
patent: 3715345 (1973-02-01), Smith
patent: 4183849 (1980-01-01), Hansen et al.
Diabetes vol. 28, Mar. 1979, 196-203.
Glucagon for Injection, USP-Jan. 1979, PA 9643 CCAP, Eli Lilly and Company (Canada) Ltd.

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