Disaggregated mutant human RANTES

Details Disaggregated mutant human RANTES Disaggregated mutant human RANTES

1997-09-25

1999-10-12

Mertz, Prema

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530412, 435 695, 435 711, 435 712, 435471, 435325, 4352523, 4353201, C07K 1452, C12N 1519, C12N 1563, C12N 510

Patent

active

059656972

ABSTRACT:
This invention relates to mutants of human RANTES (hRANTES) which, relative to the wild-type molecule, have a reduced tendency to aggregate into large multimeric complexes at physiological ionic strength and pH, and are less pro-inflammatory.

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