Disaccharide inflammation inhibitors and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 24, 514 53, 514 54, 514 61, 514 62, 536 41, 536 172, 536 179, 536 187, 536 53, 536 54, 536 55, 536 551, 536 552, 5361231, 53612313, A61K 3170, C07H 1500, C07H 1700

Patent

active

056397348

ABSTRACT:
The present invention provides a composition of matter comprising a biosynthetic anti-inflammatory oligosaccharide, comprising the structure of: sugar - sugar - X - R; wherein said sugar is selected from the group consisting of N-acetylneuraminic acid, galactose, N-acetylglucosamine, N-acetylgalactosamine, fucose and mannose; wherein X is a bridging atom selected from the group consisting of oxygen, sulfur, nitrogen and carbon; and wherein R is an aglycone selected from the group consisting of naphthol, naphthalenemethane, indenol, a heterocyclic derivative of indenol, a heterocyclic derivative of naphthol and a heterocyclic derivative of naphthalenemethanol. Also provided is a method of treating an inflammatory disease in an individual comprising the step of administering to said individual a therapeutically effective dose of the novel composition of the present invention.

REFERENCES:
patent: 5426178 (1995-06-01), Laine et al.
Lasky Science, 1992, 258, 964-969.

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