Disaccharide analogs of antitumor anthracyclines, process for th

Details Disaccharide analogs of antitumor anthracyclines, process for th Disaccharide analogs of antitumor anthracyclines, process for th

1977-11-14

1979-09-25

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 17A, A61K 3170, C07G 1100

Patent

active

041691423

ABSTRACT:
Anthracycline disaccharides having antitumor activity are prepared by condensing N-trifluoroacetyldaunomycin with a 1-halosugar in the presence of a silver salt such as AgSO.sub.3 CF.sub.3 as catalyst to form a protected di-glycoside which upon mild alkaline hydrolysis yields the novel disaccharides.

REFERENCES:
patent: 3686163 (1972-08-01), Arcamone et al.

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