Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-07
1998-08-11
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 711, 4352523, 4353201, 530324, 935 22, 935 66, C12P 2106, C12P 2104, A61K 3800, C12N 1500
Patent
active
057926247
ABSTRACT:
The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
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Richer et al., "Dirofilaria immitis: Proteases Produced by Third-and Fourth-Stage Larvae," Experimental Parasitology, vol. 75, pp. 213-222, 1992.
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Frank Glenn R.
Grieve Robert B.
Richer Jennifer K.
Tripp Cynthia Ann
Wisnewski Nancy
Colorado State University Research Foundation
Heska Corporation
Sisson Bradley L.
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