Dirofilaria and brugia thioredoxin peroxidase type-2 (TPX-2) nuc

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352351, 4352523, 4353201, 435325, 514 44, 536 235, C12N 1509, C12N 700, C12N 1500, C07H 2104

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061501352

ABSTRACT:
The present invention relates to: Dirofilaria and Brugia thioredoxin peroxidase type-2 (TPx-2) proteins; Dirofilaria and Brugia TPx-2 nucleic acid molecules, including those that encode such TPx-2 proteins; antibodies raised against such TPx-2 proteins; and compounds that inhibit Dirofilaria and Brugia TPx-2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

REFERENCES:
patent: 5744593 (1998-04-01), Klimowski et al.
Klimowski et al., 1997, Molecular and Biochemical Parasitology, 90, pp. 297-306.
Singh et al., 1995, Int. J. Biochem. Cell Biol. 27:12, pp. 1285-1291.
Blaxter et al., 1996, Int'l. Journal for Parasitology, 26:10, pp. 1025-1033.
Database Embl Nucleotide Sequence, Nov. 14, 1997, AF027387.
Database Embl Nucleotide Sequence, Mar. 10, 1998, AA842559.
Aalen, R.B., 1994, "Transcripts Encoding An Oleosin and a Dormancy-Related Protein Are Present in Both the Aleurone Layer and the Embryo of Developing Barley (Hordeum vulgare L) Seeds," Plant J., 5(3), pp. 385-396.
Cha, et al., 1996, "Purification and Characterization of Thiol-Specific Antioxidant Protein from Human Liver: A Mer5-Like Human Isoenzyme," J. Biochem. Mol. Biol., vol. 29(3), pp. 236-240.
Cha, et al., 1995, "Thioredoxin-Linked Peroxidase from Human Red Blood Cell: Evidence for the Existence of Thioredoxin and Thioredoxin Reductase in Human Red Blood Cell," Biochemical and Biophysical Research Communications, 217(3), pp. 900-907.
Chae, et al., 1994, "Cloning and sequencing of thiol-specific antioxidant from mammalian brain: Alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes," Proc. Natl. Acad. Sci. USA, 91, pp. 7017-7021.
Chae, et al., 1993, "Cloning, Sequencing, and Mutation of Thiol-Specific Antioxidant Gene of Saccharomyces cerevisiae," J. Biological Chemistry 268(22), pp. 16815-16821.
Chae, et al., 1994, "Dimerization of thiol-specific antioxidant and the essential role of cysteine 47," Proc. Natl. Acad. Sci USA, 91, pp. 7022-7026.
Chae, et al., 1994, "A thiol-specific antioxidant and sequence homology to various proteins of unknown function," BioFactors, 4(3/4), pp. 177-180.
Chae, et al., 1994, "Thioredoxin-dependent Peroxide Reductase from Yeast," J. Biological Chemistry, 269(44), pp. 27670-27678.
Ghosh, et al., 1995, "A Thiol-Specific Antioxidant from Brugia malayi L3'S," Am. J. Trop. Med. Hyg., 53(2) (Supp.), p. 197 (Abstract #332).
Ishii, et al., 1993, "Cloning and Characterization of a 23-kDa Stress-induced Mouse Peritoneal Macrophage Protein," J. Biological Chemistry, 268(25), pp. 18633-18636.
Ishii, et al., 1995, "Inhibition of the Thiol-Specific Antioxidant Activity of Rat Liver MSP23 Protein by Hemin," Biochemical and Biophysical Research Communications, 216(3), pp. 970-975.
Iwahara, et al., 1995, "Purification, characterization, and cloning of a heme-binding protein (23kDa) in rat liver cytosol," Biochemistry, 34, pp. 13398-13406.
Jacobson, et al., 1989, "An Alkyl Hydroperoxide Reductase from Salmonella typhimurium Involved in the Defense of DNA against Oxidative Damage," J. Biological Chemistry, 264(3), pp. 1488-1496.
Kawai, 1994, "Cloning and Characterization of OSF-3, a New Member of the MER5 Family, Expressed in Mouse Osteoblastic Cells," J. Biochem., 115, pp. 641-643.
Kim, et al., 1989, "Induction of an antioxidant protein of Saccharomyces cerevisiae by O.sub.2, Fe.sup.3+, or 2-mercaptoethanol," Proc. Natl. Acad. Sci. USA, 86, pp. 6018-6022.
Kim, et al., 1985, "Nonenzymatic Cleavage of Proteins by Reactive Oxygen Species Generated by Dithiothreitol and Iron," J. Biological Chemistry, 260(29), pp. 15394-15397.
Kim, et al., 1988, "The Isolation and Purification of a Specific `Protector` Protein Which Inhibits Enzyme Inactivation by a Thiol/Fe(III)/O.sub.2 Mixed-function Oxidation System," J. Biological Chemistry, 263(10), pp. 4704-4711.
Lim, et al., 1994, "Purification and Characterization of Thiol-Specific Antioxidant Protein from Human Red Blood Cell: A New Type of Antioxidant Protein," Biochemical and Biophysical Research Communications, 199(1), pp. 199-206.
Lim, et al., 1993, "Removals of Hydrogen Peroxide and Hydroxyl Radical by Thiol-Specific Antioxidant Protein as a Possible Role in vivo," Biochemical and Biphysical Research. Communications, 192(1), pp. 273-280.
Lim, et al., 1994, "The Thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions," Gene, 140, pp. 279-284.
Nagase, et al., 1995, "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of a cDNA clones from human cell line KG-1." DNA Res., 2(1), pp. 37-43.
Netto, et al., 1996, "The Iron-Catalyzed Oxidation of Dithiothreitol Is a Biphasic Process: Hydrogen Peroxide Is Involved in the Initiation of a Free Radical Chain of Reactions," Archives of Biochemistry and Biphysics, 333(1), pp. 233-242.
Netto, et al., 1996, "Removal of Hydrogen Peroxide by Thiol-specific Antioxidant Enzyme (TSA) Is Involved with Its Antioxidant Properties," J. Biological Chemistry, 271(26), pp. 15315-15321.
O'Toole, et al., 1991, "Isolation and Biochemical and Molecular Analyses of a Species-Specific Protein Antigen from the Gastric Pathogen Helicobacter pylori," J. of Bacteriology, 173(2), pp. 505-513.
Prosperi, et al., 1993, "A Human cDNA Corresponding to a Gene Overexpressed during Cell Proliferation Encodes a Product Sharing Homology with Amoebic and Bacterial Proteins," J. Biological Chemistry, 68(15), pp. 11050-11056.
Rabilloud, et al., 1995, "Early events in erythroid differentiation: accumulation of the acidic peroxidoxin (PRP/TSA/NKEF-B)," Biochem. J., 312, pp. 699-705.
Rasmussen, et al., 1992, "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes," Electrophoresis 13, pp. 960-969.
Reed, et al., 1992, "Molecular and Cellular Characterization of the 29-Kilodalton Peripheral Membrane Protein of Entamoeba histolytica: Differentiation between Pathogenic and Nonpathogenic Isolates," Infection and Immunity, 60(2), pp. 542-549.
Rhee, et al., 1994, "Antioxidant Defense Mechanisms: A New Thiol-Specific Antioxidant Enzyme," Annals New York Academy of Sciences, 738, pp. 86-92.
Rhee, et al., 1994, "Thioredoxin Peroxidase and Peroxiredoxin Family," Mol. Cells, 4, pp. 137-142.
Sauri, et al., 1995, "Antioxidant Function of Recombinant Human Natural Killer Enhancing Factor," Biochemical and Biophysical Research Communications, 208(3), pp. 964-969.
Scott, et al., 1995, "EST Analysis and Antigen Discovery from Brugia malayi L3 cDNA Libraries," Am. J. Top. Med. Hyg. 53(2) (Supp.): 196 (Abstract #330).
Shau, et al., 1994, "Cloning and sequence analysis of candidate human natural killer-enhancing factor genes," Immunogenetics, 40, pp. 129-134.
Shau, et al., 1994, "Identification of Natural Killer Enhancing Factor as a Major Antioxidant in Human Red Blood Cells," Biochemical and Biophysical Research Communications, 199(1), pp. 83-88.
Spyrou, et al., 1997, "Cloning and Expression of a Novel Mammalian Thioredoxin," J. Biological Chemistry, 272(5), pp. 2936-2941.
Torian, 1990, "cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica," Proc. Natl. Acad. Sci. USA, 87, pp. 6358-6362.
Watabe, et al., 1995, "Possible Function of SP-22, a Substrate of Mitochondrial ATP-Dependent Protease, as a Radical Scavenger," Biochemical and Biophysical Research Communications, 213(3), pp. 1010-1016.
Yamaguchi, et al., 1992, "Cloning and Expression of the Gene for the Avi-3 Antigen of Mycobacterium avium and Mapping of Its Epitopes," Infection and Immunity, 60(3), pp. 1210-1216.
Yamamoto, 1989, "Cloning of a housekeeping-type ge

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