Dirofilaria and Brugia ankyrin proteins, nucleic acid molecules,

Details Dirofilaria and Brugia ankyrin proteins, nucleic acid molecules, Dirofilaria and Brugia ankyrin proteins, nucleic acid molecules,

1997-04-24

1998-10-27

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435325, 4352351, 4352523, 536 231, C12P 2106, C12N 700, C07H 1700

Patent

active

058276920

ABSTRACT:
The present invention relates to Dirofilaria ankyrin proteins and to Brugia ankyrin proteins; to Dirofilaria ankyrin nucleic acid molecules and to Brugia ankyrin nucleic acid molecules, including those that encode such ankyrin proteins; to antibodies raised against such ankyrin proteins; and to compounds that inhibit Dirofilaria or Brugia ankyrin function. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

REFERENCES:
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Bennett, 1992, "Ankyrins: Adaptors Between Diverse Plasma Membrane Proteins and the Cytoplasm," The Journal of Biological Chemistry, 267:13, pp. 8703-8706.
Davis, et al., 1994, "Ankyrin Binding Activity Shared by the Neurofascin/L1/NrCAM Family of Nervous System Cell Adhesion Molecules," The Journal of Biological Chemistry, 269:44, pp. 27163-27166.
Erttmann, et al., 1996, "Immunohistological studies on an Onchocerca volvulus Ankryin (EI)" Tropical Medicine and International Health, 1:5, pp. 558-574.
Erttmann, et al., 1996, "Molecular Cloning, Expression, and Localization of E1, an Onchocerca volvulus Antigen with Similarity to Brain Ankyrin," The Journal of Biological Chemistry, 271:3, pp. 1645-1650.
Erttmann, et al., 1996, "The putatively protective Onchocerca volvulus neuronal protein E1 is a member of the death domain protein family," FEBS Letters 390, pp. 21-24.
Kordeli, et al., 1995, "Ankyrin.sub.G A New Ankyrin Gene with Neural-Specific Isoforms Localized at the Axonal Initial Segment and Node of Ranvier," The Journal of Biological Chemistry, 270:5, pp. 2352-2359.
Kunimoto, et al., 1991, "A New 440-kD Isoform is the Major Ankyrin in Neonatal Rat Brain," The Journal of Cell Biology, 115:5, pp. 1319-1331.
Lambert, et al., 1993, "Postmitotic Expression of Ankyrin.sub.R and .beta..sub.R -Spectrin in Discrete Neuronal Populations of the Rat Brain," The Journal of Neuroscience, 13:9, pp. 3725-3735.
Otsuka, et al., 1995, "An Ankyrin-related Gene (unc-44) is Necessary for Proper Axonal Guidance in Caenorhabditis elegans," The Journal of Cell Biology, 129:4, pp. 1081-1092.
Smith, et al., 1991, "Amiloride-sensitive sodium channel is linked to the cytoskeleton in renal epithelial cells," Proc. Natl. Acad. Sci. USA, 88, pp. 6971-6975.
Srinivasan, et al., 1988, "Ankyrin and spectrin associate with voltage-dependent sodium channels in brain," Nature, 333, pp. 177-180.

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