Directly compressible lactitol and method

Details Directly compressible lactitol and method Directly compressible lactitol and method

1996-09-19

1998-12-08

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424465, 514952, 514960, A61K 916, A61K 920, A61K 4726

Patent

active

058465685

ABSTRACT:
A directly compressible non-cariogenic free-flowing lactitol granulate comprising milled lactitol and a physiologically acceptable, binder taken from the group consisting of sugar alcohols, polymerized reducing sugars, alkali carboxymethylcellulose, hydrogenated starch hydrolysate, hydroxypropylcellulose, physiologically acceptable cellulose derivatives, polyvinylpyrrolidone, gum arabic, and other physiologically acceptable gums. The granulate is directly compressible, and manifests the taste profile, metabolic, and non-cariogenic properties of lactitol. In one embodiment, the milled lactitol is present in the granulate in the range of about 70% to about 98% by dry weight and the physiologically acceptable, non-cariogenic binder is present in the granulate in the range of about 2% to about 30% by dry weight. In a preferred embodiment of the invention, the granulate consists of 70-98% milled lactitol and 2-30% of a lactitol binder.

REFERENCES:
patent: 5021249 (1991-06-01), Bunick et al.
patent: 5204115 (1993-04-01), Olinger et al.
patent: 5322694 (1994-06-01), Sixsmith
patent: 5501861 (1996-03-01), Mizumoto et al.
patent: 5536526 (1996-07-01), Virtanen et al.
patent: 5612053 (1997-03-01), Baichwal et al.
patent: 5651988 (1997-07-01), Olinger et al.
Derwent Abstract for JP 9216816 A.

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