Directly compressible granules having improved flow properties

Details Directly compressible granules having improved flow properties Directly compressible granules having improved flow properties

1989-10-31

1992-12-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424501, 424502, A61K 914

Patent

active

051696452

ABSTRACT:
Directly compressible, wax-containing granules having improved flow properties are obtained when waxes are admixed in the melt with certain flow improving additives, followed by cooling and granulation of the admixture. In certain embodiments of the invention, only the wax itself melts in the melt combination of the wax(es) and additives(s), and in other cases both the wax(es) and the additives(s) will both melt. In either case, the melt combination of the wax(es) with the additive(s) yields, upon cooling and granulation, a wax-containing particulate drug diluent having improved and unexpected flow properties.

REFERENCES:
patent: 4521902 (1985-06-01), Dunn
patent: 4753800 (1988-06-01), Mozda
patent: 4756911 (1988-07-01), Drost et al.
patent: 4888178 (1989-12-01), Rotini et al.

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