Directly compressible acetaminophen granulation

Details Directly compressible acetaminophen granulation Directly compressible acetaminophen granulation

1982-09-22

1984-03-27

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424 34, 424 35, 424361, A61K 916, A61K 934, A61K 960, A61K 962

Patent

active

044394535

ABSTRACT:
A free flowing granulation, comprising a high concentration of acetaminophen and a low level of excipient, including ground cross-linked sodium carboxymethylcellulose fiber, allows the manufacture of analgesic tablets by direct compression. The method provides improvements in manufacturing economics and tablet properties.

REFERENCES:
patent: 4097606 (1978-06-01), Chavkin
Gissinger, Labo.-Pharma Problems & Tech., vol. 28, Jan. 1980, pp. 27-31.
Bhatia, Drug & Cos. Ind., Apr. 1978, pp. 38, 39, 42, 44, 52, 171-175.
Nautamlal, Dissertation Abs. Int., vol. 40, No. 11, May 1980, pp. 5214B-5215B.

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