Directionally cloned random cDNA expression vector...

Details Directionally cloned random cDNA expression vector... Directionally cloned random cDNA expression vector...

2006-04-25

2006-04-25

Ketter, James (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024330

Reexamination Certificate

active

07034145

ABSTRACT:
The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in antisense orientation. Methods for producing these libraries through directional cloning of random cDNAs are also provided. Also provided herein are methods of using these libraries to screen for agents capable of modulating cell phenotype in desirable ways.

REFERENCES:
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Hofmann, et al. “Rapid Retroviral Delivery of Tetracycline-Inducible Genes in a Single Autoregulatory Cassette”,Proc. Natl. Acad. Sci. USA,(1996) vol. 93: 5185-5190.
Lorens, et al. “Retroviral Delivery of Peptide Modulators of Cellular Functions”,Molecular Therapy,(2000) vol. 1(5): 438-447.
Matz, et al. “Fluorescent Proteins from Nonbioluminescent Anthozoa Species”,Nature Biotechnology,(1999) vol. 17: 969-973.
Xu, et al. “Dominant Effector Genetics in Mammalian Cells”,Nature Genetics,(2001) vol. 27:23-29.

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