Directed switch-mediated DNA recombination

Details Directed switch-mediated DNA recombination Directed switch-mediated DNA recombination

1996-03-20

1998-02-03

Elliott, George G.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4353201, 435328, 4353723, C12N 1563, C12N 1579, C12N 508, C12N 524

Patent

active

057143528

ABSTRACT:
Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between a targeting construct containing a promoter, a switch region (S.sub.1), and 2) a target locus minimally containing a promoter, a switch region (S.sub.2), and a target sequence.

REFERENCES:
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5202238 (1993-04-01), Fell et al.
Leung et al. (1994) Mol. Cell Biol. 14:1450-1458, 1994.
Harriman et al. (1993) Annu. Rev. Immunol. 11:361-384, 1993.
Dariavach, P. et al. The Mouse IgH 3'-enchancer, Eur. J. Immunol., 21:1499-1504, (1991).
Flanagan, J.G. et al., Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing .gamma., .epsilon. and .alpha. genes, Nature, vol. 300, 23/30, pp. 709-713, (Dec. 1982).
Green, L.L., et al., Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs, Nature Genetics, vol. 7, pp. 13-21, (May 1994).
Gritzmacher, C.., Molecular Aspects of Heavy-chain Class Switching, Critical Reviews in Immunology, vol. 9, Issue 3, pp. 173-200, (1989).
Honjo, T., Immunoglobulin Genes, Ann. Rev. Immunol., 1:499-528, (1983).
Marcu, K. B., et al., A model for the molecular requirements of immunoglobulin heavy chain class switching, Nature, vol. 298, 87-89, (Jul. 1, 1982).
Mills, Frederick, C., et al., Human Ig S.gamma. Regions and Their Participation in Sequential Switching to IgE, J. Immunol., 155:3021-3036, (1995).
Mowatt, M. R., et al., DNA Sequence of the Murine .gamma.1 Switch Segment Reveals Novel Structural Elements, Journal of Immunology, vol. 136, No. 7, 2674-2683, (Apr. 1, 1986).
Nikaido, T., et al., Nucleotide Sequences of Switch Regions of Immunoglobulin C.sub..epsilon., and C.sub..gamma. Genes and Their Comparison, the Journal of Biological Chemistry, vol. 257, 13:7322-7329, (Jul. 10, 1982).
Rabbits, T.H., et al., The role of gene deletion in the immunoglobulin heavy chain switch, Nature, vol. 283:351-356, (Jan. 24, 1980).
Shimizu, A., et al., Trans-Splicing as a Possible Molecular Mechanism for the Multiple Isotype Expression of the Immunoglobulin Gene, J. Exp. Med., 173:1385-1393, (Jun. 1991).
Takahashi, N., et al., Structure of Human Immunoglobulin Gamma Genes: Implications for Evolution of a Gene Family, Cell, 29:671-679, (Jun. 1982) .

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