Directed microwave chemistry

Details Directed microwave chemistry Directed microwave chemistry

2008-03-25

2008-03-25

Le, Long V. (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

C436S173000, C436S050000, C436S051000, C436S526000, C436S806000, C435S004000, C435S006120, C435S007100, C435S287100, C435S287200, C422S082010, C427S002100

Reexamination Certificate

active

10234092

ABSTRACT:
The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many small scale chemical transformations including those used in protein chemistry and in combinatorial chemistry.

REFERENCES:
patent: 3455842 (1969-07-01), Cornelius et al.
patent: 3839175 (1974-10-01), Keyes
patent: 4340672 (1982-07-01), Kondo et al.
patent: 4575485 (1986-03-01), Sizto et al.
patent: 4822492 (1989-04-01), Chao et al.
patent: 4822566 (1989-04-01), Newman
patent: 4880752 (1989-11-01), Keck et al.
patent: 5350686 (1994-09-01), Jhingan
patent: 5427779 (1995-06-01), Elsner et al.
patent: 5451428 (1995-09-01), Rupp
patent: 5478748 (1995-12-01), Akins et al.
patent: 5496701 (1996-03-01), Pollard-Knight
patent: 5689008 (1997-11-01), Satyapal et al.
patent: 5780578 (1998-07-01), Mashelkar et al.
patent: 5869349 (1999-02-01), Lin et al.
patent: 5911941 (1999-06-01), Rokhvarger et al.
patent: 5922537 (1999-07-01), Ewart et al.
patent: 5985356 (1999-11-01), Schultz et al.
patent: 6011247 (2000-01-01), Grillo et al.
patent: 6180415 (2001-01-01), Schultz et al.
patent: 0 487 091 (1992-05-01), None
patent: 1 363 526 (1974-08-01), None
Abati, A. & Liotta, L.A., “Looking Forward in Diagnostic Pathology,” (1996) Cancer 78, 1-3.
Baziard, Y & Gourdenne, A, Cross-linking Under Microwaves (2.45 GHz) of Aluminum Powder-Epoxy Resin Composites I. Electrical Power Dependence (1988) Eur. Polym. J. 24, 873.
Boon, M.E. & Kok, L.P. (1989) in Microwave Cookbook of Pathology, p. 17, Coulomb Press, Leiden.
Boon, M.E. “Microwave Cookbook of Pathology,” Coulomb Press Leyden 1989, 1-219.
Borchart, A. & Still, W.C., Synthetic Receptor Binding Elucidated with an Encoded Combinatatorial Library, (1994) J. Am. Chem. Soc. 116, 373.
Borman, S., “Combinatorial Chemistry,” (2001) Chem Engineer. News Aug. 27, 2001, pp. 49-58.
Bose, A.K. et al. “MORE Chermistry in a Microwave,” (1997) CHEMTECH 27(9), 18-25.
Bowie, A.R., Sanders, M.G., & Worsfold, P.J. (1996), “Analytical Applications of Liquid Phase Chemiluminescence Reactions—A Review,” J. Biolumin. Chemilumin. 11, 61-90.
Bram, G. et al. “Alkylation of Potassium Acetate in “Dry Media” Thermal Activation In Commercial Microwave Ovens,” (1990) Tetrahedron 46, 5167.
Bram, G., Loupy, A., Majdoub, M., and Petit, A., “Anthraquinone Microwave-Induced Synthesis In Dry Media in Domestic Ovens,” (1991) Chem. Ind. 396.
Breslow, R. et al. (1983), “Optimization of Metallocene Substrates for Beta-Cyclodextrin Reactions,” J. Am. Chem. Soc. 105, 2739.
Buffler, C.R. & Risman, P.O. (1996), “Microwave Processing of Materials,” Mat. Res. Soc. Symp. Proc. 430, 85.
Burow, M. & Minoura, N., “Molecular Imprinting: Synthesis of Polymer Particles with Antibody-like Binding Characteristics for Glucose Oxidase,” (1996) Biochem. Biophys. Res. Commun. 227, 419.
Bystrom, S.E. et al., “Selective Reduction of Steroid 3- and 17-Ketones Using LiAlH4 activated Template Polymers,” (1993) 115, 2081.
Cooper, C.S., “Applications of Microarray Technology in Breast Cancer Research,” (2001) Breast Cancer Res. 3, 158-175.
Dai, S. et al., “Imprint Coating: A Novel Synthesis of Selective Functionalized Ordered Mesoporous Sorbents,” (1999) Angew. Chem. Int. Ed. 38, 1235.
Dickert, FL & Thierer S, “Molecularly Imprinted Polymers for Optichemical Sensors,” (1996) Adv. Mater. 8, 987.
Dolle, R.E., “Comprehensive Survey of Combinatorial Library Synthesis: 1999,” (2000) J. Comb. Chem. 2, 383-433.
Draghici, S. et al., “Experimental Design, Analysis of Variance and Slide Quality assessment in Gene Expression Arrays,” (2001) Curr. Opin. Drug Discov. Dev. (2001) 4, 332-337.
Fodor, S.P.A. et al. “Multiplexed Biochemical Assays With Biological Chips,” (1993) Nature 364, 555-556.
Folkman, J. “Angiogenesis and Angiogenesis Inhibition: An Overview,”(1997) EXS 79, 1-8.
Freeman, W.M. et al. “Quantitative RT-PCR: Pitfalls and Potential,” Walker, S.J., & Vrana, K.E. (1999) BioTechniques 26, 112-125.
Gabriel, C. et al. “Dielectric Parameters Relevant to Microwave Dielectric Heating,” (1998) Chem. Soc. Rev. 27, 213-224.
Gallop, M.A. et al., “Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries,” (1994) J. Med. Chem. 37(9), 1233-1251.
Glad et al., “Use of Silane Monomers for Molecular Imprinting and Enzyme Entrapment in Polysiloxane-Coated Porous Silica,” (1985) J. Chromatogr. 347, 11.
Gordon, E.M. et al., “Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies and Future Directions,” (1994) J. Med. Chem. 37(10), 385-401.
Gu, W. et al., “Photo-Fries Reactions of 1-Naphthyl Esters in Cation-Exchanged Zeolite Y and Polyethylene Media,” (1999) J. Am. Chem. Soc. 121, 9467.
Harkin, D.P., “Uncovering Functionally Relevant Signalling Pathways Using Microarray-Based Expression Profiling,” (2000) Oncologist 5, 501-7.
Hasted, J.B., “Aqueous Dielectrics,” (1973) chapman & Hall, London, 1-255.
Hergenrother, P.J. et al. “Small-Molecule Microarrays: Covalent Attachment and Screening of Alcohol-Containing Small Molecules on Glass Slides,” (2000) J. Amer. Chem. Soc. 122, 7849-7850.
Hilpert, K. et al. “Anti-c-myc Antibody 9E10: Epitope Key Positions and Variability Characterized Using Peptide Spot Synthesis on Cellulose,” (2001) Prot. Engineer. 14, 803-806.
Holzworth, A. et al., “Enhanced Microwave Heating of Nonpolar Solvents by Dispersed Magnetic Nanoparticles,” Ind. Eng. Chem. Res. (1998) 37, 2701.
Huhmer, A.F.R. and Landers, J.P, “Noncontact Infrared-Mediated Thermocycling for Effective Polymerase Chain Reaction Amplification of DNA in Nanoliter vol.,” (2000) Anal. Chem. 72, 5507-5512.
Jacobs, J.W. et al. “Combinatorial Chemistry—Applications of Light-Directed Chemical Synthesis,” (1994) Trends Biotechnol. 12, 19-26.
Jiang, P. et al., “Template-Directed Preparation of Macroporous Polymers with Oriented and Crystalline Arrays of Voids,” (1999) J. Am. Chem. Soc. 121, 11630.
Jin, Q. et al., “Application of Microwave Techniques in analytical Chemistry,” (1999) Trends Anal. Chem. 18, 479-484.
Johnson, B., “All's Well That Ends Well: A Profile of Specialty Microwell Plates,” (1999) The Scientist 13, 16.
Jones, K.D., “Membrane Immobilization of Nucleic Acids: Part 1: Substrates,” IVD (2001) Technology 7(6) 50-54.
Kappe, C.O. “Speeding Up Solid-Phase Chemistry By Microwave Irradiation: A Tool for High-Throughput Synthesis,” (2001) American Laboratory 23, 13-19.
Kappe, C.O., “High-Speed Combinatorial Synthesis Utilizing Microwave Irradiation,” (2002) Curr. Opin. Chem. Biol. 6, 314-320.
Kempe et al., “An Approach Towards Surface Imprinting Using the Enzyme Ribonuclease A,” (1995) J. Mol. Recog. 8, 35.
Kidwai, M., Kohli, S., Saxena, R.K., Gupta, R., and Bardoo, S., “A Novel Enzymatic Synthesis of 2-substituted Naphtho[2,1-b]-pyran-3-ones Using Microwaves,” (1998) Ind. J. Chem.37B, 963.
Korbel, G.A. et al., “Reaction Microarrays: A Method for Rapidly Determining the Enantiomeric Excess of Thousands of Samples,” (2001) J. Am. Chem. Soc. 123, 361-362.
Kramer, A. et al., Synthesis and Screening of Peptide Libraries on Continuous Cellulose Membrane Supports, (1998) Methods Molec. Biol. 87, 25-39.
Kricka, L.J., “Nucleic Acids Detection Technologies—Labels Strategies, and Formats,”

Affiliated with

Also associated with

Rating

Directed microwave chemistry does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Directed microwave chemistry, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Directed microwave chemistry will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3939050