Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-04-15
2010-10-05
Lu, Frank W (Department: 1634)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S006120, C435S091100, C435S252300, C435S320100
Reexamination Certificate
active
07807408
ABSTRACT:
Disclosed is a method of altering a nucleic acid such as RNA or DNA. The method comprises fragmenting a parent nucleic acid strand to generate nucleic acid fragments. At least a subset of the fragments are ligated to generate shuffled nucleic acid strands. A selected strand is identified from the shuffled nucleic acid strands for a criterion. The methods of the invention can also be used to diversify proteins.
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Bittker Joshua A.
Liu David R.
Liu Jane M.
Engellenner Thomas J.
Lu Frank W
Nutter & McClennen & Fish LLP
President & Fellows of Harvard College
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