Directed evolution of microorganisms

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using bacteria

Reexamination Certificate

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C435S069100, C435S440000, C435S441000, C435S233000, C435S234000, C435S252300, C435S183000, C435S173800, C435S195000, C435S479000, C435S481000, C435S482000, C435S471000

Reexamination Certificate

active

07125695

ABSTRACT:
The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.

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