Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-03-09
1993-10-12
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352541, C12P 1718, C12N 114
Patent
active
052524710
ABSTRACT:
Compounds of Structural Formula (I) ##STR1## are produced by directed biosynthesis. These compounds are squalene synthetase inhibitors useful as cholesterol-lowering agents.
REFERENCES:
Baxter et al., Squalestatin 1, A Potent Inhibitor of Squalene Synthase Which Lowers Serum Cholesterol in Vivo, J. Biol. Chem., vol. 267, pp. 11705-11708 (1992).
Byrne Kevin M.
Kaplan Louis
Omstead Mary N.
DiPrima Joseph F.
Dolan Catherine A.
Merck & Co. , Inc.
Robinson Douglas W.
Sevigny Jeffrey J.
LandOfFree
Directed biosynthesis of cholesterol lowering compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Directed biosynthesis of cholesterol lowering compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Directed biosynthesis of cholesterol lowering compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1903909