Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-08-27
1994-03-15
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514397, 514414, 514444, 514452, 546270, 5483117, 548463, 549 601, 549363, H61K 31335, H61K 3138, C07D49308
Patent
active
052946274
ABSTRACT:
Compounds of Structural Formula (I) ##STR1## are produced by directed biosynthesis. These compounds are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.
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Arison Bryon H.
Chen Shieh-Shung T.
Petuch Brian R.
White Raymond F.
Dolan Catherine A.
Matukaitis Paul D.
Merck & Co. , Inc.
Raymond Richard L.
Winokur Melvin
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