Directed apoptosis in COX-2 overexpressing cancer cells...

Details Directed apoptosis in COX-2 overexpressing cancer cells... Directed apoptosis in COX-2 overexpressing cancer cells...

2004-12-23

2009-12-29

Marvich, Maria B (Department: 1633)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

C435S455000, C435S456000, C435S458000, C435S320100, C435S465000

Reexamination Certificate

active

07638331

ABSTRACT:
The present invention provides methods and constructs for selectively expressing an Apoptosis-Inducing Gene (AIG) in a population of cells that overexpress cyclooxygenase-2 (COX-2) to induce apoptosis in the cell. To achieve this goal a chimeric gene construct is used that comprises a cyclooxygenase-2 promoter (COX-2 promoter) that is operably linked to at least one AIG such that the COX-2 promoter is activated in cells that overexpress COX-2, thereby resulting in transcription and translation of the AIG, which in turn activates apoptosis in the cell. Thus, apoptosis is selectively induced in only those cells capable of overexpressing COX-2.

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