Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1987-02-13
1988-07-12
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
264118, 424 80, 424465, 514849, A61K 914
Patent
active
047570903
ABSTRACT:
An N-acetyl-p-aminophenol composition capable of being directly formed into a tablet having high hardness, short disintegration time and short dissolution time is disclosed. The composition includes N-acetyl-p-aminophenol, a pharmaceutically acceptable pregelatinized starch, a pharmaceutically acceptable lubricant, water and optionally an auxiliary binder such as polyvinylpyrrolidone. Also disclosed is a method for preparing the composition which includes drying a fluidized bed of the composition in a fluid bed granulator-dryer.
REFERENCES:
patent: 2798838 (1957-07-01), Robinson
patent: 2876160 (1959-03-01), Schoch et al.
patent: 3181998 (1965-05-01), Kanig
patent: 3453368 (1969-07-01), Magid
patent: 3499962 (1970-03-01), Wurzburg et al.
patent: 3786123 (1974-01-01), Katzen
patent: 3851032 (1974-11-01), Andrews et al.
patent: 3923974 (1975-12-01), Andrews et al.
patent: 4072535 (1978-02-01), Short et al.
patent: 4327080 (1982-04-01), Wong et al.
patent: 4661521 (1987-04-01), Salpekar et al.
Salpekar, Anil M.: "A Study of Some Important Aspects of Tablet Lubrication"-Ph.D. Dissertion/Univ. Maryland, 1975.
Starch 1500.RTM. Colorcon, Inc. brochure, 14 pages (including front and back covers).
Dr. rer. nat. Paul Heinz List, "Arzneiformenlehr", 1976, p. 74, (Original and translation) [2 pages].
Lactose-U.S.P. Fast-FLo, Foremost Foods Company brochure, 1977, 8 pages.
"Plasdone.RTM. Povidone USP", GAF Corp. Bulletin No. 2302-2310, (1981), 14 pages.
"Prototype Formulation: Acetaminophen Tablets", Colorcon, Inc. Technical Data Bulletin, (2/81), 2 pages.
"Evaluation of Starch 1500 As a Gradulation Binder in the Formulation of Acetaminophen Tablets", Colorcon, Inc. Technical Data Bulletin, (2/81-per private communication dated Feb. 15, 1984, Anil M. Salpekar, 6 pages.
Denton Larry E.
Salpekar Anil M.
Griffin Ronald W.
Mallinckrodt Inc.
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