Direct tableting acetaminophen compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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264118, 424 80, 424465, 514849, A61K 914

Patent

active

046615210

ABSTRACT:
An N-acetyl-p-aminophenol composition capable of being directly formed into a tablet having high hardness, short disintegration time and short dissolution time is disclosed. The composition includes N-acetyl-p-aminophenol, a pharmaceutically acceptable pregelatinized starch, a pharmaceutically acceptable lubricant, water and optionally an auxiliary binder such as polyvinylpyrrolidone. Also disclosed is a method for preparing the composition which includes drying a fluidized bed of the composition in a fluid bed granulator-dryer.

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