Radiant energy – Ionic separation or analysis – With sample supply means
Patent
1998-04-08
2000-12-26
Berman, Jack
Radiant energy
Ionic separation or analysis
With sample supply means
356316, 31511151, 2191215, 21912151, 21912152, H01J 4904, G01J 310
Patent
active
061663794
ABSTRACT:
A simple, relatively low-cost direct injection high efficiency nebulizer (DIHEN) is suitable for argon inductively coupled plasma (Ar ICP) spectrometry. The DIHEN may be operated at solution uptake rates of 1-100 .mu.L/min. Analytical performance indices for the DIHEN and fundamental characteristics of the aerosol produced are obtained using an ICP mass spectrometer (ICPMS) and a 2-dimensional phase Doppler particle analyzer (2D PDPA), respectively. Results are compared to those obtained with a conventional crossflow pneumatic nebulizer (PN), equipped with a Scott-type spray chamber. Droplet sizes and velocities produced with the DIHEN are smaller than those reported for the direct injection nebulizer (DIN). The DIHEN offers optimal sensitivity at low injector gas flow rates (approx. 0.25 L/min) and high RF power (approx. 1.5 kW). For the 17 elements tested, detection limits (ppt) and sensitivities achieved with the DIHEN (at 85 .mu.L/min) are similar to or better than those obtained on the same instrument using the PN (at 1 mL/min). However, because the primary aerosol is injected directly into the plasma, oxide-to-metal ion ratios (MO.sup.+ /M.sup.+) are high as in the case of the DIN. The utility of the DIHEN for the analysis of small volume samples is demonstrated by microscale flow injection analysis (.mu.FIA) of Cr bound to human lung DNA. Detection of Cr at the femtogram level is feasible.
REFERENCES:
patent: 3467471 (1969-09-01), Greenfield et al.
patent: 4575609 (1986-03-01), Fassel et al.
patent: 4989976 (1991-02-01), Huber
patent: 4990740 (1991-02-01), Meyer
patent: 5212365 (1993-05-01), Wiederin
patent: 5867262 (1999-02-01), Etoh et al.
B. Sharp, "Pneumatic Nebulisers and Spray Chambers for Inductively Coupled Plasma Spectrometry: A Review, Part 1. Nebulisers", J. Anal. At. Spectrom., 1988, vol. 3, pp. 613-652.
S-H. Nam et al., "High-Efficiency Nebulizer for Argon Inductively Coupled Plasma Mass Spectrometry", J. Anal. At. Spectrom., 1994, vol. 9, pp. 1357-1362.
H. Liu et al., "Evaluation of a Low Sample Consumption, High-efficiency Nebulizer for Elemental Analysis of Biological Samples Using Inductively Coupled Plasma Mass Spectrometry", J. Anal. At. Spectrom., 1996, vol. 11, pp. 307-311.
Liu et al., "Phase-Doppler Diagnostic Studies of Primary and Tertiary Aerosols Produced by a High-Efficiency Nebulizer", Anal. Chem., 1994, vol. 66, pp. 3233-3242.
Liu et al., "Investigation of a high-efficiency nebulizer and a thimble glass frit nebulizer for elemental analysis of biological materials by inductively coupled plasma-atomic emission spectrometry", Spectrochim. Acta 1996, vol. 51B, pp. 27-40.
Olesik et al., "Inductively Coupled Plasma Optical Emission Spectrometry Using Nebulizers with Widely Different Sample Consumption Rates", Anal. Chem., 1994, vol. 66, pp. 2022-2030.
Pergantis et al., "Microscale Flow Injection and Microbore High-Performance Liquid Chromatography Coupled with Inductively Coupled Plasma Mass Spectrometry via High-Efficiency Nebulizer",Anal. Chem., 1995, vol. 67, pp. 4530-4535.
Vanhaecke et al., "Evaluation of a Commercially Available Microconcentric Nebulizer for Inductively Coupled Plasma mass Spectrometry", J. Anal. At. Spectrom., 1996, vol. 11, pp. 543-548.
Augagneur et al., "Determination of Rare Earth Elements in Wine by Inductively Coupled Plasma Mass Spectrometry Using a Microconcentric Nebulizer", J. Anal. At. Spectrom., 1996, vol. 11, pp. 713-721.
Lawrence et al., "Direct Liquid Sample Introduction for Flow Injection Analysis and Liquid Chromatography with Inductively Coupled Argon Plasma Spectrometric Detection", Anal. Chem., 1984, vol. 56, pp. 289-292.
LaFreniere et al., "Flow Injection Analysis with Inductively Coupled Plasma-atomic Emission Spectroscopy: Critical Comparison of Conventional Pneumatic, Ultrasonic and Direct Injection Nebulization", Spectrochim. Acta 1985, vol. 40B, pp. 1495-1504.
LaFreniere et al., "Elemental Speciation via High-Performance Liquid Chromatography Combined with Inductively Coupled Plasma Atomic Emission Spectroscopic Detection: Application of a Direct Injection Nebulizer", Anal. Chem., 1987, vol. 59, pp. 879-887.
Avery et al., "Characterization and Optimization of a Direct Injection Nebulizer for Introduction of Organic Solvents and Volatile Analyte Species into a Inductively Coupled Plasma", Appl. Spectrosc., 1990, vol. 44, pp. 1690-1698.
Wiederin et al., "Direct Injection Nebulization for Inductively Coupled Plasma Mass Spectrometry", Anal. Chem., 1991, vol. 63, pp. 219-225.
Wiederin et al., "On-Line Standard Additions with Direct Injection Nebulization for Inductively Coupled Plasma Mass Spectrometry", Anal. Chem., 1991, vol. 63, pp. 1626-1631.
Smith et al., "Measurement of boron concentration and isotope ratios in biological samples by inductively coupled plasma mass spectrometry with direct injection nebulization", Analytica Chimica Acta, 1991, vol. 248, pp. 229-234.
Shum et al., "Speciation of Mercury and Lead Compounds by Microbore Column Liquid Chromatography--Inductively Coupled Plasma Mass Spectrometry with Direct Injection Nebulization", Anal. Chem., 1992, vol. 64, pp. 2444-2450.
Shum et al., "Elemental Speciation by Liquid Chromatography--Inductively Coupled Plasma Mass Spectrometry With Direct Injection Nebulization", Analyst. 1992, vol. 117, pp. 577-582.
Powell et al., "Inductively Coupled Plasma Mass Spectrometry with Direct Injection Nebulization for Mercury Analysis of Drinking Water", Anal. Chem., 1992, vol. 64, pp. 2253-2257.
Shum et al., "Elemental Speciation by Anion Exchange and Size Exclusion Chromatography with Detection by Inductively Coupled Plasma Mass Spectrometry with Direct Injection Nebulization", Anal. Chem., 1993, vol. 65, pp. 2972-2976.
Powell et al., "Determination of Chromium Species in Environmental Samples Using High-Pressure Liquid Chromatography Direct Injection Nebulization and Inductively Coupled Plasma Mass Spectrometry", Anal. Chem., 1995, vol. 67, pp. 2474-2478.
Zoorob et al., "Evaluation of the Direct Injection Nebulizer in the Coupling of High-Performance Liquid Chromatography to Inductively Coupled Plasma Mass Spectrometry", J. Anal. At. Spectrom., 1995, vol. 10, pp. 853-858.
Liu et al., "Capillary Electrophoresis Coupled On-Line with Inductively Coupled Plasma Mass Spectrometry for Elemental Speciation", Anal. Chem., 1995, vol. 67, pp. 2020-2025.
Wiederin et al., "Measurement of Aerosol Particle Sizes from a Direct Injection Nebulizer", Appl. Spectrosc., 1991, vol. 45, pp. 1408-1412.
Shum et al., "Spatially Resolved Measurements of Size and Velocity Distributions of Aerosol Droplets from a Direct Injection Nebulizer", App. Spectrosc., 1993, vol. 47, pp. 575-583.
Christodoulou et al., "Determination of Gold and Platinum in the Presence of Blood Plasma Proteins Using Inductively Coupled Plasma Mass Spectrometry with Direct Injection Nebulization", J. Anal. At. Spectrom., 1996, vol. 11, pp. 1031-1035.
French et al., "Monodisperse Dried Microparticulate Injector for Analytical Instrumentation", Anal. Chem., 1994 vol. 66, pp. 685-691.
Olesik et al., "Monodisperse Dried Microparticulate Injector: A New Tool for Studying Fundamental Processes in Inductively Coupled Plasmas", Anal. Chem., 1994, vol. 66, pp. 3371-3378.
Dziewatkoski et al., "Time-Resolved Inductively Coupled Plasma Mass Spectrometry Measurements with Individual, Monodisperse Drop Sample Introduction", Anal. Chem., 1996, vol. 68, pp. 1101-1109.
Allen et al., "Spatial Location of the Space Charge Effect in Individual Ion Clouds Using Monodisperse Dried Microparticulate Injection with a Twin Quadrupole Inductively Coupled Plasma Mass Spectrometer", Anal. Chem., 1997, vol. 69, pp. 2384-2391.
Olesik, "Investigating the Fate of Individual Sample Droplets in Inductively Coupled Plasmas", Appl. Spectrosc. 1997, vol. 51, pp. 158A-175A.
Olesik et al., "Observation of Atom and Ion Clouds Produced From Single Droplets of Sample in Inductively Coupled Plasmas by Optical Emission and Laser-Induced Fluorescence Imaging", Appl. Spectrosc., 1997, vol. 51, pp. 607-616.
Lazar et al., "Investigation of the Analytical
Kacsir Jerold M.
McLean John A.
Montaser Akbar
Berman Jack
George Washington University
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