Direct influences on nerve growth of agents that interact with i

Details Direct influences on nerve growth of agents that interact with i Direct influences on nerve growth of agents that interact with i

1994-04-12

1999-04-27

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514291, A61K 3818, A61K 31435

Patent

active

058980296

ABSTRACT:
Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.

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