Direct flow injection analysis nebulization electrospray and...

Details Direct flow injection analysis nebulization electrospray and... Direct flow injection analysis nebulization electrospray and...

2005-02-22

2005-02-22

Soderquist, Arlen (Department: 1743)

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

C250S281000, C250S282000, C250S285000, C250S288000

Reexamination Certificate

active

06858437

ABSTRACT:
A method and apparatus for Flow Injection Analysis (FIA) into Atmospheric Pressure Ion sources (API) including Electrospray (ES) and Atmospheric Pressure Chemical Ionization (APCI) sources whereby the sampling and spray needles are one and the same. The sampling and spray needle configured with an autoinjector apparatus or used in manual injection is introduced directly into a mating ES or APCI probe configured in an API source. Such a sampling and spray needle eliminates the need for injector valves, transfer lines or additional fluid delivery systems in FIA into API sources interfaced to mass spectrometers or other chemical analyzers. The use of a sampling and spray needle configuration reduces component costs, liquid dead volume, sample dilution effects, and minimizes cross contamination effects, solvent consumption and waste while increasing sample throughput.

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