Direct detection of hepatitis C virus RNA

Details Direct detection of hepatitis C virus RNA Direct detection of hepatitis C virus RNA

1994-11-08

1999-06-22

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 911, 435 912, 536 231, 536 243, 536 2432, 536 2433, C12Q 170, C12Q 168, C12P 1934, C07H 2104

Patent

active

059142286

ABSTRACT:
The methods and compositions of this invention provide a fast, accurate means for directly determining the presence and quantity of HCV in a sample, and thus in a patient, through hybridization to patient samples using a probe specific for HCV. They allow detection of both acute and chronic HCV infection. These methods and compositions also allow for the effective monitoring of therapeutic procedures for treating HCV infection.

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patent: 5350671 (1994-09-01), Houghton et al.
patent: 5372928 (1994-12-01), Miyamura
Houghton, Michael et al., "Molecular Biology of the Hepatitis C Viruses: Implications for Diagnosis, Development and Control of Viral Disease," Hepatology, 14:381-388 (Aug. 1991).
Choo et al. Science 244:359-362, 1989.
Okamoto et al Japan J. Exp. Med vol. 60(3) pp. 167-177 issued Feb. 1990.
Takeuchi et al. J. of Gen. Virology vol. 71 pp. 3027-3033 issued Dec. 1990.
Kato et al. Proc. Natl. Acad. Sci USA vol. 87 pp. 9524-9528 issued Dec. 1990.

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