Direct detection of bacteria-antibody complexes via UV...

Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...

Reexamination Certificate

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C356S300000, C356S301000, C356S302000, C356S303000, C356S307000, C356S319000, C356S326000, C356S451000, C435S004000, C435S007100, C435S007200, C435S007320, C435S007370, C435S034000, C435S038000, C436S164000, C436S173000, C436S532000, C436S804000

Reexamination Certificate

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06844199

ABSTRACT:
A system for the detection of bacteria based on bacteria-antibody complexes. Bacteria attached to antibody are detected with resonance Raman spectroscopy. The bacteria are detected directly in a great numerical excess, e.g. 100 to 10,000 of antibody molecules. A sample to be tested is placed in a medium, the medium containing antibodies attached to a surface for binding to a specific bacteria to form an antigen to antibody complex. The medium is contacted with a beam of light energy. The bacteria, as a lower resonance enhanced Raman backscattered energy, is analyzed for the presence or absence of the bacteria.

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