Direct compression tablet binders for acetaminophen

Details Direct compression tablet binders for acetaminophen Direct compression tablet binders for acetaminophen

1988-01-12

1990-01-16

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424476, 424502, A61K 926

Patent

active

048942367

ABSTRACT:
Dry, directly compressed tablets are provided by a blend of from 60 to 90 weight percent of acetaminophen and from 10 to 40 weight percent of non-ionizable lipid having a melting point of from 55.degree. C. to 80.degree. C. The preferred lipid is hydrogenated cotton seed oil. The tablets are characterized by a hardness of at least 5 kgs. When produced by a conventional tabletting machine using a pressure of 1.5 to 20 tons per square inch.

REFERENCES:
patent: 3873694 (1975-03-01), Kanig
patent: 4327076 (1982-04-01), Puglia et al.
patent: 4327077 (1982-04-01), Puglia et al.
patent: 4375468 (1983-01-01), Dunn
patent: 4401665 (1983-08-01), Sheinaus et al.
patent: 4439453 (1984-03-01), Vogel
patent: 4562024 (1985-12-01), Rogerson
patent: 4590062 (1986-05-01), Jang
patent: 4661521 (1987-04-01), Salpekar et al.
patent: 4670251 (1987-06-01), Blanco
patent: 4704269 (1987-11-01), Korab
"Problem Solver" A reference manual by FMC Corp. p. IV-A-11.

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