Direct compression metformin hydrochloride tablets

Details Direct compression metformin hydrochloride tablets Direct compression metformin hydrochloride tablets

1998-08-25

2000-09-12

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424468, 424489, 514770, 5147723, 514777, 514781, 514784, 514951, 514960, A61K 920, A61K 922

Patent

active

061174513

ABSTRACT:
Metformin Hydrochloride (herein referred to as metformin HCl) that may be 98.5%-100% pure is a high dose drug capable of being directly compressed with specific excipients into tablets having desired, hardness, disintegrating ability, and acceptable dissolution characteristics. Metformin HCl is not inherently compressible and thus presents formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow metformin HCl to be compressed using the direct compression method. The tablets produced provide an acceptable in-vitro dissolution profile.

REFERENCES:
patent: 5955106 (1999-09-01), Moeckel et al.

Affiliated with

Also associated with

Rating

Direct compression metformin hydrochloride tablets does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Direct compression metformin hydrochloride tablets, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Direct compression metformin hydrochloride tablets will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-93289