Direct compression cyclophosphamide tablet

Details Direct compression cyclophosphamide tablet Direct compression cyclophosphamide tablet

1988-09-09

1991-09-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424470, 424475, 424479, 424499, A61K 930

Patent

active

050472461

ABSTRACT:
A directly compressible pharmaceutical composition comprising cyclophosphamide and a partially or fully pregelatinized starch is disclosed. The pharmaceutical composition, when directly compressed into a tablet, exhibits unexpected stability when compared to cyclophosphamide in combination with other direct compression vehicles.

REFERENCES:
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patent: 3725556 (1973-04-01), Hanssen et al.
patent: 3873694 (1975-03-01), Kanig
patent: 4072535 (1978-01-01), Short et al.
patent: 4198507 (1980-04-01), Barry et al.
patent: 4218471 (1980-08-01), Brock et al.
patent: 4439453 (1984-03-01), Vogel
patent: 4457907 (1984-07-01), Porter
patent: 4753789 (1988-06-01), Tyers et al.
patent: 4910218 (1990-03-01), Bair

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