Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1989-03-16
1990-09-11
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424482, A61K 942
Patent
active
049561820
ABSTRACT:
A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.
REFERENCES:
patent: 3383237 (1968-05-01), Tuerck
patent: 4895723 (1990-01-01), Amer et al.
P. A. Tuerck, et al., J. Pharm. Sci., vol. 62, 1534-37 (1973).
Bequette Robert J.
Bonenberger Bruce A.
Gallian Claude E.
Reckelhoff John R.
Bristol-Myers Company
Page Thurman K.
Uloth Robert H.
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