Dipyrazoles and their use as bronchodilators

Details Dipyrazoles and their use as bronchodilators Dipyrazoles and their use as bronchodilators

1987-01-27

1988-03-29

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548369, 548371, A61K 31415, C07D23154, C07D23156

Patent

active

047344300

ABSTRACT:
A group of variously methyl-substituted[1,2-c:3,4-c']dipyrazoles, cyclohepta[1,2-c:3,4-c']dipyrazoles, and cyclopenta[1,2-c:3,4-c']dipyrazoles useful as bronchodilators are described herein. The compounds are prepared by reacting a 1,3-diketone with hydrazine or methylhydrazine to give tricyclic products optionally followed by catalytic dehydrogenation and/or alkylation with a strong base and methyl iodide to give various other compounds within the scope of the invention.

REFERENCES:
patent: 3404157 (1968-10-01), McEvoy et al.
patent: 4515948 (1985-05-01), Kompis et al.
G. Spiteller, G. Schmidt, H. Budzikiewicz, F. Wessely, CA54:17377i (1960).
F. Wessely, H. Budzikiewicz, H. Janda, CA55:25922b (1961).
I. A. Strakova, A. Ya Strakov, E. Gudriniece, Latv. PSR, Zinat Akad Vestis, Kim Ser, 5:610-14 (1974); (CA82:43247w) (1975).
E. Gudriniece, I. A. Strakova, A. Ya Strakov, CA82:4172y (1975).

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