Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-01-14
1997-08-12
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
422 56, 422 57, 435 79, 435 792, 435 21, 435 26, 435 28, 435962, 435963, 435970, 435975, 4352872, 4352877, 435805, 435810, 436518, 436527, 436530, 436531, 436169, 436808, 436810, G01N 3353, G01N 33548
Patent
active
056564481
ABSTRACT:
The invention pertains to dipstick immunoassay devices. The device comprises a base member and a single, combined sample contact zone and test zone, wherein the test zone incorporates the use of symbols to detect analytes in a sample of biological fluid. A first immunological component, an anti-immunoglobulin capable of binding to an enzyme-labeled antibody, is immobilized in a control indicia portion. A second immunological component, capable of specifically binding to a target analyte which is bound to the enzyme-labeled antibody to form a sandwich complex, is immobilized in a test indicia portion. The enzyme-labeled antibody produces a visual color differential between a control indicia portion and a non-indicia portion in the test zone upon contact with a substrate. The device additionally includes a first polyol and a color differential enhancing component selected from the group consisting of an inhibitor to the enzyme and a competitive secondary substrate for the enzyme distributed throughout the non-indicia portion of the test zone.
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Colanduoni John A.
Kang Jemo
Kang Walter J.
Lee Dong Joon
Ok Chiyoung
Housel James C.
Princeton Biomeditech Corporation
Wolski Susan C.
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