Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-06-08
1999-06-29
Minnifield, Nita
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
4241831, 4241841, 4241851, 4242031, 4242361, 4242451, 4242391, 435 691, 435 697, 435 29, C07K 100, A61K 3900, A61K 3908, C12P 2104
Patent
active
059170174
ABSTRACT:
Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Corynebacterium diphtheria.
REFERENCES:
patent: 4709017 (1987-11-01), Collier et al.
patent: 5601827 (1997-02-01), Collier et al.
patent: 5733726 (1998-03-01), Fu et al.
Aron, R., "Synthetic Vaccines" published 1987 by CRC Press (FL), pp. 40-71.
Haughten et al. 1986. Vaccines 86. New Approaches to Immunization. pp. 21-25. Fred Brown et al eds.
Davis et al (ed.) 1980. Immunology. pp. 291-295.
Rolf et al. 1991. ASM. Annual Mtg. Abstract Gen. Mtg. ASM. 91:75 Abs. # B-296.
Greenfield et al. 1987. Mutations in Diphtheria Toxin Separate . . . Science 238:536-539.
Killeen et al. 1992. Reversion of recombinant toxoids: Mutations in diphtheria toxin . . . PNAS 89:6207-6209.
Rolf et al. 1990. Localization of the diphtheria toxin receptor-binding . . . JBC. 265(13):7331-7337.
Fu et al. 1993. Receptor-binding domain of diphtheria toxin as a potential immunogen. Vaccines 93, pp. 379-383.
Bixler et al. 1987. B Cell Recognition of Protein Antigens . . . In:Synthetic Vaccines (ed. Arnon). vol. 1 pp. 39-71.
Anderson, "Antibody Responses to Haemophilus Influenzae Type B and Diphtheria Toxin Induced by Conjugates of Oligosaccharides of the Type b Capsule with the . . . ," Infection and Immunity 39:233-238, 1983.
Anderson et al., "Immunogens Consisting of Oligosaccharides from the Capsule of Haemophilus influenzae Type b Coupled to Diphtheria Toxoid or the Toxin Protein CRM197," J Clin Invest 76:52-59, 1985.
Anderson et al., "Effect of Oligosaccharide Chain Length, Exposed Terminal Group, and Hapten Loading on the Antibody Response of Human Adults and Infants to Vaccines . . . ," J of Immunology 142:2464-2468, 1989.
Arnon, "Synthetic Peptides as the Basis for Future Vaccines," Trends Biochem. 11:521-524, 1986.
Baseman et al., "Action of Diphtheria Toxin in the Guinea Pig," J. Exp. Med. 132:1138-1152, 1970.
Boquet et al., "Studies on the Role of a Nucleoside-Phosphate-Binding Site of Diphtheria Toxin in the Binding of Toxin to Vero Cells or Liposomes," Eur. J. Biochem. 121:93-98, 1981.
Choe et al., "The Crystal structure of Diphtheria Toxin," Nature 357:216-222, 1992.
Eskola et al., "Antibody Levels Achieved in Infants by Course of Haemophilus Influenzae Type B Polysaccharide/Diphtheria Toxoid Conjugate Vaccine," Lancelet 1:1184-1186, 1985.
Giannini et al., "The Amino Acid Sequence of Two Non-Toxic Mutants of Diphtheria Toxin: CRM45 and CRM197," Nucleic Acids Research 12:4063-4069, 1984.
Greenfield et al., "Nucleotide Sequence of the Structural Gene for Diphtheria Toxin Carried by Corynebacteriophage B," Proc. Natl Acad Sci USA 80:6853-6857, 1983.
McGill et al., "Membrane Interactions of Diphtheria Toxin Analyzed using in vitro Synthesized Mutants," The EMBO Journal 8:2843-2848, 1989.
Rolf et al., "Further Characterization of the Diphtheria Toxin Receptor-Binding Domain within HA6DT," 1991, 75th Annual Mtg FASEB J. 5:A821, #2619.
Rolf et al., "Structure-Function Analyses of Diphtheria Toxin by Use of Monoclonal Antibodies," Infection & Immunity 61:994-1003, 1993.
Tang et al., "Genetic Immunization is a Simple Method for Eliciting an Immune Response," Nature 356:152-154 1992.
Uchida et al., "Mutation in the Structural Gene for Diphtheria Toxin Carried by Temperate Phage 6," Nature New Biology 233:8-11, 1971.
Wen et al., "Diphtheria Toxin-Related .alpha.-Melanocyte-Stimulating Hormone Fusion Toxin," J. Biol. Chem. 266: 12289-12293, 1991.
Zucker et al., "Monoclonal Antibody Analysis of Diphtheria Toxin-I. Localization of Epitopes and Neutralization of Cytotoxicity," Molecular Immunology 21:785-793, 1984.
Zucker et al., "Monoclonal Antibody Analysis of Diphtheria Toxin-II. Inhibition of ADP-Ribosyl-Transferase Activity," Molecular Immunology 21:795-800, 1984.
Choe Seunghyon
Collier R. John
Eisenberg David
Shen Wei Hai
Minnifield Nita
President and Fellows of Harvard College
The Regents of the University of California
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