Diphosponylated oxonitriles, processes and uses therefor, and co

Details Diphosponylated oxonitriles, processes and uses therefor, and co Diphosponylated oxonitriles, processes and uses therefor, and co

1987-03-16

1988-01-12

Evans, J. E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26050112, 424 49, 514 76, 514108, C07F 938, A61K 716, A61K 748

Patent

active

047190507

ABSTRACT:
3-Alkyl-3-oxo-1-aminopropane-1,1-diphosphonic acids and water-soluble salts thereof corresponding to the formula ##STR1## in which R.sup.1 represents an unbranched or branched C.sub.1 -C.sub.8 alkyl group, R.sup.2 and R.sup.3 independently of one another represent methyl or ethyl, and each M represents H or a cation of a water-soluble base, to a process for producing these compounds wherein oxonitriles corresponding to the formula: ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 are as defined above, are reacted with mixtures of a phosphorus trihalide PX.sub.3, where X represents fluorine, chlorine or bromine, with phosphorous acid, the reaction mixture is hydrolyzed, and the reaction products are optionally converted into water-soluble salts; and to the use of the resulting compounds corresponding to general formula (III).

REFERENCES:
patent: 3899496 (1975-08-01), Schindler et al.
patent: 4006182 (1977-02-01), Ploger et al.
patent: 4239695 (1980-12-01), Chai et al.
patent: 0054195 (1982-06-01), EPX European Pat. Off.

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