Diphosphonic acid derivatives

Details Diphosphonic acid derivatives Diphosphonic acid derivatives

1986-03-31

1987-05-19

Evans, J. E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

2605025C, 546 22, 548112, 548119, 548413, 548414, C07F 938, A61K 31045, A61K 3116, A61K 3166

Patent

active

046668950

ABSTRACT:
The present invention provides diphosphonic acid derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently of one another or also together, signify hydrogen atoms or lower alkyl radicals, whereby R.sub.1 and X or R.sub.3 and Y or R.sub.4 and Z, together with the nitrogen atom to which they are attached, can form a five- or six-membered ring, X and Y, which can be the same or different, represent a straight-chained or branched alkylene chain with up to 6 carbon atoms which can optionally be substituted by aromatic or heteroaromatic radicals, Z is a straight-chained or branched alkylene chain with up to 6 carbon atoms, which can be interrupted by heteroatoms and can optionally also be substituted by aromatic or heteroaromatic radicals, n is 0, 1 or 2 and A is a hydrogen atom or a hydroxyl group, and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these new diphosphonic acid derivatives and pharmaceutical compositions containing them for the treatment of calcium metabolism disturbances.

REFERENCES:
patent: 3899496 (1975-08-01), Schindler et al.
patent: 3979385 (1976-09-01), Wallmann et al.
patent: 4029697 (1977-06-01), Krueger et al.
patent: 4134969 (1979-01-01), Schmidt-Dunker
patent: 4239695 (1980-12-01), Chai et al.
patent: 4503049 (1985-03-01), Biere et al.

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